A Role for Enhanced Functions of Sleep in Psychedelic Therapy?

This is the start of a fascinating new collaboration: we found that psilocybin can mitigate the negative effects of sleep disruption on memory consolidation in a dose-dependent manner!

I am particularly excited given that sleep disruption in this paradigm, the Morris Water Maze, has been proposed as surrogate for understanding pathological and aging-related loss of memory functions in humans!

Here is the paper:

A role for enhanced functions of sleep in psychedelic therapy?

Tom Froese, Iwin Leenen, and Tomas Palenicek

After a hiatus of several decades there has been a resurgence of studies into the therapeutic potential of serotonergic psychedelics. When administered in controlled settings, they have been reported to induce a wide variety of long-lasting positive psychological changes. However, the mechanisms by which psychedelics impart these long-lasting benefits remain poorly understood. Here we highlight one possibility that has remained underexplored: a beneficial interaction with the self-optimizing functions of sleep.

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